Announcement_ru2795

I gave a talk at the annual meeting of Synapses Under Stress (RU 2795), hosted by Prof. Jürgen Klingauf at the University of Münster, Germany. My talk was titled Alzheimer’s Disease-associated Intracellular Calcium Dyshomeostasis Leads to Impaired Presynaptic Function, and I shared key results from the initial phases of my thesis. This work focuses on the cellular level disruptions associated with Ca²⁺ signaling in Familial Alzheimer’s Disease (FAD), including the effects of disrupted Ca²⁺ signaling on neurotransmitter release and synaptic plasticity in an in-silico model of FAD, and how Aβ-mediated cation pore formation modulates presynaptic Ca²⁺ dynamics and the downstream effects on exocytosis in-silico.